factory supplier 17α-estradiol 57-91-0 exporter CAS NO.57-91-0

Estradiol Usage And Synthesis

Chemical Properties White Solid

Uses Estradiol (known as α-Estradiol or 17 α-Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture. 17-Εstradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer’s disease and ischemic stroke.

Definition ChEBI: An estradiol that is estra-1,3,5(10)-triene substituted by hydroxy groups at positions 3 and 17 (the 17alpha stereoisomer).

Biological Activity Endogenous estrogen receptor ligand (K i values are 0.2 and 1.2 nM for ER α and ER β receptors respectively).

Purification Methods 17-Estradiol recrystallises from aqueous EtOH (80%) as the hemihydrate and differs from the -anomer (below) by not precipitating with digitonin in 80% aqueous EtOH. The diacetate [1474-52-8] crystallises from aqueous EtOH in needles with m 139-140o. The 3-benzoate crystallises in three forms m 158o, 153o and 63o.

Function

1. Inadequate estrogen supplementation. Used in the treatment of female gonadal dysfunction, bilateral ovariectomy, atrophic vaginitis, desiccation of the vulva, climacteric syndrome such as hot flashes, sweating and mental and nerve symptoms.

2. Use estrogen to treat metastatic breast cancer, 40 % can achieve relief.

3. To treat advanced prostate cancer, symptoms are markedly improved, pain is reduced, testicular removal is followed by estrogen treatment.

4. Prevent osteoporosis and prevent rapid bone loss due to estrogen deficiency.

Treatment of acne(acne) can be used in heavier cases in men and a combination of estrogen and progesterone in women.

6. Leucopenia, used in malignant tumor caused by chemotherapy or radiotherapy leukopenia, has the effect of obviously raising the white blood cells.

7. Use as an after-pill.

8. Milk withdrawal.

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